Publications

Synthesis and metabolism of BTN3A1 ligands: studies on diene modifications to the phosphoantigen scaffold. Harmon, N. M.; Huang, X.; Poe, M. M.; Foust, B. J..; Hsiao, C. C.; Wiemer, D. F.; Wiemer, A. J.; ACS Med. Chem. Lett. 2022, 13, 164-170.
Relative efficiency of bis-amidate phosphonate prodrugs of a butyrophilin ligand, Lentini, N. A.; Huang, X.; Schladetsch, M. A.; Hsiao, C. C.; Wiemer, D. F.; Wiemer, A. J. Bioorg. Med. Chem. Lett. 2022, 128724.
Conjugate addition to vinyl bisphosphonates as a route to unsymmetrically substituted dialkyl bisphosphonates, Harmon, N. M.; Gehrke, N. R.; Wiemer, D. F.; Tetrahedron Letters, 2022, 106, 154078.
Substitution of a triazole for the central olefin in biologically active stilbenes, Stockdale, D. P.; Beutler, J. A.; Wiemer, D. F. Bioorg. Med. Chem. Lett. 2022, 75, 128980.

Synthesis and metabolism of BTN3A1 ligands: studies on modifications of the allylic alcohol, Lentini, N. A.; Schroeder, C.; Harmon, N. M.; Huang, X.; Schladetsch, M. A.; Foust, B. J.; Hsiao, C. C.; Poe, M. M.; Wiemer, A. J.; Wiemer, D. F. ACS Med. Chem. Lett. 2021, 12, 136–142.
Incorporation of a FRET Pair within a Phosphonate Diester, Harmon, N. M.; Huang, X.; Hsiao, C. C.; Wiemer, A. J.; Wiemer, D. F. Bioorganic Chemistry, 2021, 114, 105048.
Impact of a-modifications on the activity of triazole bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. Fairweather, A. E. R.; Goetz, D. B.; Schroeder, C.; Bhuiyan, N. H.; Varney, M. L.; Wiemer, D. F.; Holstein, S. A. Bioorg. Med. Chem. 2021, 116307.
Synthesis of a Coumarin-Based Analogue of Schweinfurthin F. Schroeder, C.; Dey, P. N. Beutler, J. A.; Wiemer, D. F. J. Org. Chem. 2021, 86, 16824–16833.

Amides as Bioisosteres of Triazole-Based Geranylgeranyl Diphosphate Synthase Inhibitors, Goetz, D. B.; Varney, M. L.; Wiemer, D. F.; Holstein, S. A. Bioorg. Med. Chem. 2020, 28, 115604.
Potent Double Prodrug Forms of Synthetic Phosphoantigens, Harmon, N. M.; Huang, X.; Schladetsch, M. A.; Hsiao, C. C.; Wiemer, A. J.; Wiemer, D. F. Bioorg. Med. Chem. 2020, 28, 115666.

Stability and efficiency of mixed aryl phosphonate prodrugs. Foust, B. J.; Li, J.; Hsiao, C. C.; Wiemer, A. J.; Wiemer, D. F. ChemMedChem 2019, 14, 1597-1603.
Synthesis and bioactivity of the phosphonamidate stereoisomers derived from a Butyrophilin ligand. Lentini, N. A.; Hsiao, C. C.; Crull, G. B.; Wiemer, A. J.; Wiemer, D. F. ACS Med. Chem. Lett. 2019,10, 1284–1289.
ω-Hydroxy isoprenoid bisphosphonates as linkable GGDPS inhibitors. Bhuiyan, N. H.; Varney, M. L.; Bhattacharya, D. S.; Payne, W. M.; Mohs, A. M.; Holstein, S. A; Wiemer, D. F. Bioorg. Med. Chem. Lett. 2019, 29, 126633.
A luciferase lysis assay reveals in vivo malignant cell sensitization by phosphoantigen prodrugs. Li, J. Lentini, N. A.; Wiemer, D. F.; and Wiemer, A. J. Biochem. Pharm. 2019, 170, 113668.
Novel benzimidazole phosphonates as potential inhibitors of protein prenylation, Bhuiyan, N. H.; Varney, M. L.; Wiemer, D. F.; Holstein, S. A. Bioorg. Med. Chem. Lett. 2019, 29, 126575..

Phosphonamidate prodrugs of a butyrophilin ligand display extended plasma stability and potent Vγ9Vδ2 T cell stimulation. Lentini, N. A.; Foust, B. J.; Hsiao, C. C.; Wiemer, A. J.; Wiemer, D. F. J. Med. Chem. 2018, 61, 8658–8669. PMID: 30199251.
Chemo-enzymatic synthesis of the exocyclic olefin isomer of thymidine monophosphate. Mondal, D.; Koehn, E. M.; Yao, J.; Wiemer, D. F.; Kohen, A. Bioorg. Med. Chem. 2018, 26, 2365-2371. PMID: 29606487.
Synthesis of bavachromanol from resorcinol via a tandem cationic cascade/EAS sequence. Shah, P. A.; Wiemer, D. F. Tetrahedron Lett. 2018, 59, 1363-1365.
Quantitative Determination of a Potent Geranylgeranyl Diphosphate Synthase Inhibitor using LC-MS/MS: Derivatization and Application, Chhonker, Y. S.; Haney, S. L.; Matthiesen, R. A.; Wiemer, D. F.; Holstein, S. A; Murry, Daryl J. Journal of Pharmaceutical and Biomedical Analysis, 2018, 153, 22-28. PMID: 29455093.
α-Methylation Enhances the Potency of Isoprenoid Triazole Bisphosphonates as Geranylgeranyl Diphosphate Synthase Inhibitors. Mattheissen, R. A.; Varney, M. L.; Xu, P.; Rier, A. S.; Wiemer, D. F.; Holstein, S. A. Bioorg. Med. Chem. 2018, 26, 376-385. PMID: 29248353.

Olefin Isomers of a Triazole Bisphosphonate Synergistically Inhibit Geranylgeranyl Diphosphate Synthase. Allen, C.;Kortagere, S.; Tong, H.; Mattheissen, R. A.; Metzger, J. I.; Wiemer, D. F.; Holstein, S. A. Mol. Pharm. 2017, 91, 229-236. PMID: 28057800.
Phosphinophosphonates and their tris-pivaloyloxymethyl prodrugs reveal a negatively cooperative butyrophilin activation mechanism. Shippy, R. R.; Lin, X.; Agabiti, S. S.; Li, J.; Zangari, B. M.; Foust, B. J.; Poe, M. M.; Hsiao, C. C.; Vinogradova, O.; Wiemer, D. F.; Wiemer, A. J. J. Med. Chem., 2017, 60, 2373-2382. PMID: 28218845.
Bishomoisoprenoid triazole bisphosphonates as inhibitors of geranylgeranyl diphos-phate synthase. Wills, V. S.; Metzger, J. I.; Allen, C.; Varney, M. L.; Wiemer, D. F.; Holstein, S. A. Bioorg. Med. Chem. 2017, 25, 2437-2444. PMID: 28302510.
Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors. Haney, S. L.; Wills, V. S.; Wiemer, D. F.; Holstein, S. A. Molecules 2017, 22, 886-897. PMID: 28555000
Selective opioid growth factor receptor antagonists based on a stilbene isostere. Stockdale, D. P.; Titunick, M. B.; Biegler, J.; Hartung, A. M.; Wiemer, D. F.; McLaughlin, P. J.; Neighbors, J. D. Bioorg. Med. Chem. 2017, 25, 4464-4474. PMID: 28693915.
Mixed Aryl phosphonate prodrugs of a Butyrophilin 3A1 ligand. Foust, B. J.; Poe, M. M., N. A., Hsiao, C. C.; Wiemer, A. J.; Wiemer, D. F. ACS Med. Chem. Lett. 2017, 8, 914-918. Featured article. PMID: 28947936
Synthesis of Amide Isosteres of Schweinfurthin-based Stilbenes. Stockdale, D. P.; Beutler, J. A.; Wiemer, D. F. Bioorg. Med. Chem. 2017, 25, 5483–5489 (13) PMID: 28866376.

Stereoselective Synthesis of Homoneryl and Homogeranyl Triazole Bisphosphonates. Mattheissen, R. A.; Wills, V. S.; Metzger, J. I.; Holstein, S. A.; Wiemer, D. F. J. Org. Chem. 2016, 81, 9438–9442. PMID: 27648672.
A New Motif for Inhibitors of Geranylgeranyl Diphosphate Synthase. Foust, B. J.; Allen. C.; Holstein, S. A.; Wiemer, D. F. Bioorg. & Med. Chem. 2016, 24, 3734-3741. PMID: 27338660.
Stereocontrolled regeneration of olefins from epoxides. Wills, V. S.; Zhou, X.; Allen, C.; Holstein, S. A.; Wiemer, D. F. Tetrahedron Lett. 2016, 57, 1335–1337. PMID: 26955189.
Selective Prenylation of Protected Phenols for Synthesis of Pawhuskin A Analogues. Gardner, K. D.; Wiemer, D. F. J. Org. Chem. 2016, 81, 1585–1592. PMID: 26771823.
Evaluation of a 7-methoxycoumarin-3-carboxylic acid ester derivative as a fluorescent, cell-cleavable, phosphonate protecting group . Wiemer, A. J.; Shippy, R. R.; Kilcollins, A. M.; Li, J.; Hsiao, C. C.; Barney, R. J.; Geng, M. L.; Wiemer, D. F. ChemBioChem, 2016, 17, 52–55. PMID: 26503489.

A selective delta opioid receptor antagonist based on a stilbene core. Hartung, Alyssa M.; Navarro, Hernan A.; Wiemer, David F.; Neighbors, Jeffrey D. Bioorg. Med. Chem. Lett. 2015, 23, 5532–5535.
In vitro studies in a myelogenous leukemia cell line suggest an organized binding of geranylgeranyl diphosphate synthase inhibitors. Reilly Jacqueline E; Zhou Xiang; Wiemer David F; Tong Huaxiang; Kuder Craig H; Hohl Raymond J. Biochem. Pharmacol. 2015, 96, 83–92.
N-Oxide derivatives of 3-(3-pyridyl)-2-phosphonopropanoic acids as potential inhibitors of Rab geranylgeranylation. Zhou Xiang; Born Ella J; Allen Cheryl; Holstein Sarah A; Wiemer David F. Bioorg. Med. Chem. Lett. 2015, 11, 2331–2334.
Potent Triazole Bisphosphonate Inhibitor of Geranylgeranyl Diphosphate Synthase. Wills, Veronica S.; Allen, Cheryl; Holstein, Sarah A.; Wiemer, David F. ACS Med. Chem. Lett. 2015, 12, 1195–1198.
Synthesis and biological evaluation of a phosphonate phosphoantigen prodrug. Hsiao, C. C.; Lin, X.; Barney, R. J.; Shippy, R. R.; Li, J.; Vinogradova, O.; Wiemer, D. F.; Wiemer, A. J. Phosphorus, Sulfur, Silicon Relat. Elem. 2015, 190, 751–753.

Prodrugs of organophosphorus compounds: crossing the membrane barrier. Wiemer, A. J. and Wiemer, D. F. in Topics in Current Chemistry (128) Phosphorus Chemistry, Montchamp, J. L., editor. 2014.
Synthesis of a phosphoantigen prodrug that potently activates Vγ9Vδ2 T-lymphocytes. Hsiao, C. C.; Lin, X.; Barney, R. J.; Shippy, R. R.; Li, J.; Vinogradova, O.; Wiemer, D. F.; Wiemer, A. J. Chemistry & Biology 2014, 21, 945–954.
Synthesis of isoprenoid bisphosphonate ethers through C-P bond formations: potential inhibitors of geranylgeranyl diphosphate synthase. Zhou, X.; Reilly, J. M.; Loerch, K. A.; Hohl, R. J.; Wiemer, D. F. Beilstein – J. Org. Chem. 2014, 10, 1645–1650.
Opportunities and challenges in development of phosphoantigens as Vγ9Vδ2 T cell agonists. Wiemer, D. F.; Wiemer, A. J. Biochemical Pharmacology, 2014, 89, 301–312.
Geranyl and Neryl Triazole Bisphosphonates as Inhibitors of Geranylgeranyl Diphosphate Synthase. Zhou, X.; Feree, S. D.; Wills, V. S.; Born, E. J.; Tong, H.; Wiemer, D. F.; Holstein, S. A. Bioorg. Med. Chem. 2014, 22, 2791–2798.
Structure Activity Relationships of Schweinfurthin Indoles. Kodet, J. G.; Beutler, John A.; Wiemer, D. F. Bioorg. Med. Chem. 2014, 22, 2542–2552.
Stilbenes as κ-selective, non-nitrogenous opioid receptor antagonists. Hartung, A. M.; Beutler, J. A.; Navarro, H. A.; Wiemer, D. F.; Neighbors, J. D. J. Nat. Prod. 2014, 77, 311-319.

Synthesis of Indole Analogues of the Natural Schweinfurthins. Kodet, J. G.; Wiemer, D. F. J. Org. Chem. 2013, 78, 9291 - 9302.
Electronic aromatic prenylation via cascade cyclization, Kodet, J. G.; Topczewski, J. J.; Gardner, K. D.; Wiemer, D. F. Tetrahedron, 2013, 69, 9212 - 9218.
Triazole-based inhibitors of geranylgeranyl transferase II. Zhou, X. Hartman, S.; Born, E. J. Smits, J. P.; Holstein, S. A.; Wiemer, D. F. Bioorg. Med. Chem. Lett.2013, 23, 764–766.
Direct Conversion of Benzylic and Allylic Alcohols to Phosphonates, Richardson, R. M.; Wiemer, D. F. Organic Synthesis 2013, 90, 145 – 152.

Synthesis of dialkyl and diaryl benzylphosphonates through a ZnI₂-mediated reaction. Richardson, R. M.; Barney, R. J.; Wiemer, D. F. Tetrahedron Lett. 2012, 53.
Functional evaluation of a fluorescent schweinfurthin: Mechanism of cytotoxicity and intracellular quantification. Kuder, C. H.; Neighbors, J. D.; Wiemer, D. F.; Hohl, R. J. Mol. Pharm.2012, 82, 9–16.

Exploration of Cascade Cyclizations Terminated By Tandem Aromatic Substitution: Total Synthesis of (+)-Schweinfurthin A. Topczewski, J. J.; Kodet, J. G.; Wiemer, D. F. J. Org. Chem. 2011, 76, 909–919.
First Total Synthesis of (+)-Vedelianin, a Potent Anti-Proliferative Agent. Topczewski, J. J.; Wiemer, D. F. Tetrahedron Letters, 2011, 52, 1628–1630.
A direct conversion of benzylic and allylic alcohols to phosphonates. Barney, R. J.; Richardson, R. M.; Wiemer, D. F. J. Org. Chem. 2011, 76, 2875–2879.
Geranylgeranyl diphosphate synthase: emerging therapeutic target. Wiemer, A. J.; Wiemer, D. F.; Hohl, R. J. Nature: Clinical Pharmacology and Therapeutics, 2011, 90 805–812.
Synthesis and Reactivity of Alkyl-1,1,1-trisphosphonate Esters. Smits, J. P.; Wiemer, D. F. J. Org. Chem. 2011, 76, 8807–8813. DOI: 10.1021/jo201523w
A Novel Bisphosphonate Inhibitor of Squalene Synthase combined with a Statin and Nitrogenous Bisphosphonate in vitro. Wasko, B. M.; Smits, J. P.; Shull, L. W.; Wiemer, D. F., and Hohl, R. J. Lipid Research, 2011, 52, 1957–1964.
Relevance of the C-5 Position to Schweinfurthin Induced Cytotoxicity. Topczewski, J. J.; Callahan, M. P.; Kodet, J. G.; Inbarasu, J. D.; Mente, N. R.; Beutler, J. A.; and Wiemer, D. F. Bioorg. Med. Chem. 2011, 19, 7570–7581.

Structural analogues of schweinfurthin F: Probing the steric, electronic, and hydrophobic properties of the D-ring substructure. Ulrich, N. C.; Kodet, J. G.; Mente, N. R.; Kuder, C. H.; Beutler, J. A.; Hohl, R. J.; Wiemer, D. F. Bioorg. Med. Chem. 2010, 18, 1676–1683.
Schweinfurthin A Selectively Inhibits Proliferation and Rho Signaling in Glioma and Neurofibromatosis type 1 Tumor Cells in an NF1-GRD Dependent Manner. Turbyville, T. J.; Gürsel, D.; Tuskan, R. G.; Walrath, J. C.; Lipshultz, C. A.; Lockett, S.; Wiemer, D. F.; Beutler, J. A.; Reilly, K. M. Mol. Cancer Ther. 2010, 9, 1234–1243.
Isoprenoid metabolism as a therapeutic target in Gram-negative pathogens. Wiemer, A. J.; Hsiao, C. C.; Wiemer, D. F. Current Topics in Medicinal Chemistry 2010, 10, 1858–1871.
Fluorescent schweinfurthin B and F analogues with anti-proliferative activity. Topczewski, J. J.; Kuder, C. H.; Neighbors, J. D.; Hohl, R. J.; Wiemer, D. F. Bioorg. Med. Chem. 2010, 18, 6734–6741.
Synthesis and biological evaluation of a series of aromatic bisphosphonates. Barney, R. J.; Wasko, B. M.; Dudakovic, A.; Hohl, R. J.; Wiemer, D. F. Bioorg. Med. Chem. 2010, 18, 7212–7220.
Biologically active biotin derivatives of schweinfurthin F. Ulrich, N. C.; Kuder, C. H.; Hohl, R. J.; Wiemer, D. F. Bioorg. Med. Chem. Letters, 2010, 20, 6716–6720.

The Intermediate Enzymes of Isoprenoid Metabolism as Anticancer Targets. Wiemer, A. J.; Hohl, R. J.; Wiemer, D. F. Anticancer Agents in Medicinal Chemistry, 2009, 9 526-542 (invited review).
Synthesis and biological activity of a fluorescent schweinfurthin analogue. Kuder, C. H.; Neighbors, J. D.; Hohl, R. J.; Wiemer, D. F. Bioorg. Med. Chem. 2009, 17, 4718-4723.
Hypericum in Infection: Identification of Anti-viral and Anti-inflammatory Constituents. Birt, D.F.; Widrlechner, M. P.; Hammer, K. D. P.; Hillwig, M. L.; Wei, J.; Kraus, G. A.; Murphy P. A.; McCoy, J.; Wurtele, E. S.; Neighbors, J. D.; Wiemer, D. F.; Maury, W. J.; Price, J. P. Pharmaceutical Biology, 2009, 47, 774-782.
Synthesis of the cis-fused hexahydroxanthene skeleton via cationic cascade cyclization. Neighbors, J. D.; Topczewski, J. J.; Swenson, D. C.; Wiemer, D. F. Tetrahedron Letters, 2009, 50, 3881–3884.
Identification of light-independent inhibition of human immunodeficiency virus-1 infection through bioguided fractionation of Hypericum perforatum. Maury, W.; Price, J.; Brindley, M. A.; Oh, C. S.; Neighbors, J. D.; Wiemer, D. F.; Wills, N.; Carpenter, S.; Hauck, C.; Murphy, P.; Widrlechner, M. P.; Delate, K.; Kumar, G.; Kraus, G. A.; Rizshsky, L.; Nikolau, B. Virology Journal, 2009, 6, 101.
Total Synthesis of (+)-Schweinfurthins B and E. Topczewski, J. J.; Neighbors, J. D.; Wiemer, D. F. J. Org. Chem. 2009, 74, 6965–6972.
A Tandem Cascade Cyclization-Electrophilic Aromatic Substitution: Application in the Total Synthesis of (+)-Angelichalcone. Topczewski, J. J.; Callahan, M. P.; Neighbors, J. D.; Wiemer, D. F. J. Am. Chem. Soc. 2009, 131,14630–14631.

Mono- and Dialkyl Isoprenoid Bisphosphonates as Geranylgeranyl Diphosphate Synthase Inhibitors. Wiemer, A. J.; Yu, J. S.; Lamb, K. M; Hohl, R. J.; Wiemer, D. F. Bioorg. Med. Chem. 2008, 16, 390–399.
Synthesis of the schweinfurthin hexahydroxanthene core through Shi epoxidation. Neighbors, J. D.; Mente, N. R.; Boss, K. D.; Zehnder, D. W. II; Wiemer, D. F. Tetrahedron Letters, 2008, 49, 516–519.
Pivaloyloxymethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation. Wiemer, A. J.; Yu, J. S.; Shull, L. W.; Barney, R. J.; Wasko, B. M.; Lamb, K. M; Hohl, R. J.; Wiemer, D. F. Bioorg. Med. Chem. 2008, 16, 3652–3660.
BF₃·Et₂O Mediated Cascade Cyclizations: Synthesis of Schweinfurthins F and G. Mente, N. R.; Neighbors, J. D.; Wiemer, D. F. J. Org. Chem. 2008, 73, 7963–7970.
Pseudohypericin is necessary for the light-activated inhibition of Prostaglandin E₂ production by Hypericum perforatum. Hammer, K. D. P.; Hillwig, M. L.; Neighbors, J. D.; Sim, Y. J.; Kohut, M. L.; Wiemer, D. F.; Wurtele, E. S.; Birt, D. F. Phytochemistry, 2008, 69, 2354–2362.
A Concise Synthesis of Pawhuskin A. Neighbors, J. D.; Buller, M. J.; Boss, K. D.; Wiemer, D. F. J. Natural Products 2008, 71, 1949-1952.

Synthesis of Fluorescently Tagged Isoprenoid Bisphosphonates that Inhibit Protein Geranylgeranylation. Maalouf, M. A.; Wiemer, A. J.; Kuder, C. H.; Hohl, R. J.; Wiemer, D. F. Bioorg Med. Chem. 2007, 15, 1959–1966.
Total Synthesis of R,R,R- and S,S,S-Schweinfurthin F: Divergence of Bioactivity in the Enantiomeric Series. Mente, N. R.; Wiemer, A. J.; Neighbors, J. D.; Beutler, J. A.; Hohl, R. J.; Wiemer, D. F. Bioorg Med. Chem. Letters, 2007, 17, 911–915.
Characterization of (E,E)-farnesol and its fatty acid esters from anal scent glands of nutria (Myocastor nutria) by GC-MS and GC-IR. Lee, H.; Finckbeiner, S.; Yu, J.S.; Wiemer, D. F.; Eisner, T.; Attygalle, A. B. J. Chromatography A 2007, 1165, (1-2), 136-143.
Temperature Effects on Stereocontrol in the Horner-Wadsworth-Emmons Condensation with a-Phosphono Lactones. Yu, J. S.; Wiemer, D. F. J. Org. Chem. 2007, 72, 6263–6265.

Synthesis and Structure-Activity Studies of Schweinfurthin B Analogs: Evidence for the Importance of a D-Ring Hydrogen Bond Donor in Expression of Differential Cytoxicity. Neighbors, J. D.; Salnikova, M. S.; Beutler, J. A.; Wiemer, D. F. Bioorg. Med. Chem. 2006, 14, 1771–1784.
The Schweinfurthins: Issues in Development of a Plant-Derived Anticancer Lead. Beutler, J. A.; Jato, J.; Cragg, G.; Wiemer, D. F.; Neighbors, J. D.; Salnikova, M. S.; Hollingshead, M.; Scudiero, D. A.; McCloud, T. G. In: Medicinal and Aromatic Plants, edited by R. J. Bogers, Springer, 2006. 301-309.
Synthesis and Biological Activity of Isoprenoid Bisphosphonates. Shull, L. W.; Wiemer, A. J.; Hohl, R. J.; Wiemer, D. F. Bioorg. Med. Chem. 2006, 14, 4130–4136.

Copper-Mediated Displacements of Allylic THP Ethers on a Bisphosphonate Template. Shull, L. W.; Wiemer, D. F. J. Organomet. Chem. 2005, 690, 2521–2530.
Synthesis of Nonracemic 3-Deoxyschweinfurthin B. Neighbors, J. D.; Beutler, J. A.; Wiemer, D. F. J. Org. Chem. 2005, 70, 925–931.
Total synthesis of pawhuskin C: A directed ortho metallation approach. Neighbors, J. D.; Salnikova, M. S.; Wiemer, D. F. Tetrahedron Letters 2005, 46, 1321–1324.
Application of benzyl protecting groups in the synthesis of prenylated aromatic compounds. Odejinmi, S. I.; Wiemer, D. F. Tetrahedron Letters 2005, 46, 3871–3874.
Synthesis of Arieianal, a Prenylated Benzoic Acid from Piper arieianum. Odejinmi, S. I.; Wiemer, D. F. J. Natural Products 2005, 68, 1375–1379.
Synthesis of Aromatic Phosphates via Cycloaddition of Phosphate Dienes. Kim, M. K.; Wiemer, D. F. Tetrahedron Letters 2005, 46, 7583–7587.
Synthesis of Farnesol Isomers via a Modified Wittig Procedure. Yu, J. S.; Kleckley, T. S.; Wiemer, D. F. Org. Letters 2005, 7, 4803–4806.

Modern Phosphonate Chemistry. by Phillippe Savignac and Bogdan Iorga. (invited book review) Wiemer, D. F. J. Am. Chem. Soc. 2004, 126, 5333–5334.
EDC-Mediated condensations of 1-chloro-5-hydrazino-9,10-anthracenedione, 1-hydrazino-9,10-anthracenedione, and the corresponding anthrapyrazoles. Kim, M. K.; Wiemer, D. F. Tetrahedron Lett. 2004, 45, 4977–4980.
Synthesis and Activity of Fluorescent Isoprenoid Pyrophosphate Analogues. Kim, M. K.; Kleckley, T. S.; Wiemer, A. J.; Holstein, S. A.; Hohl, R. J.; Wiemer, D. F. J. Org. Chem. 2004, 69, 8186–8193.

Tripeptide Probes for Tripeptidyl Protease I Production via Gene Transfer. Kim, M.; Mao, Q.; Davidson, B. L.; Wiemer, D. F. J. Med. Chem. 2003, 46 1603–1608.
Isoprenoid Pyrophosphate Analogues Regulate Expression of Ras-related Proteins. Holstein, S. A.; Wohlford-Lenane, C. L.; Wiemer, D. F.; Hohl, R. J.; Biochemistry 2003, 42, 4384–4391.
Addition of allylindium reagents to acyl phosphonates: Synthesis of tertiary a-hydroxy alkylphosphonates. Kim, D. Y.; Wiemer, D. F. Tetrahedron Lett. 2003, 44, 2803–2805.
Synthesis of 5’-Amino-5’-Phosphonate Analogs of Pyrimidine Nucleoside Monophosphates. Chen, X.; Wiemer, D. F.; J. Org. Chem. 2003, 68, 6108–6114.
a-Phosphono Lactone Analogues of Cytidine and Cytosine Arabinoside Diphosphates: Synthesis via Ring Closing Metathesis. Chen, X.; Wiemer, D. F.; J. Org. Chem. 2003, 68, 6597–6604.

Phosphonate Analogs of Cytosine Arabinoside Monophosphate. Chen, X.; Jung, K. Y.; Wiemer, D. F.; Wiemer, A. J.; Hohl, R. J. Phosphorus, Sulfur, Silicon Relat. Elem. 2002, 177, 1783–1786.
Synthesis of N-Alkyl a-Phosphonolactams via Enolate Chemistry. Du, Y.; Wiemer, D. F. Phosphorus, Sulfur, Silicon Relat. Elem. 2002, 177, 2133.
Tandem Reduction-Reductive Alkylation of Azido Sugars. Chen, L.; Wiemer D. F. Tetrahedron Lett. 2002, 43, 2705–2708.
a-Phosphono Lactone Analogues of Farnesyl Pyrophosphate: An Asymmetric Synthesis via Ring Closing Metathesis. Du, Y.; Wiemer, D. F. J. Org. Chem. 2002, 67, 5701–5708.
Preparation of a-Phosphono Lactams via Electrophilic Phosphorus Reagents: An Application in Synthesis of Lactam-Based Farnesyl Transferase Inhibitors. Du, Y.; Wiemer, D. F. J. Org. Chem. 2002, 67, 5709–5717.
Chiral Liquid Chromatography and Chiroptical Properties of the Enantiomers of Dimethyl a-Hydroxyfarnesylphosphonate, a precursor of an FPTase Inhibitor. Caccamese, S.; Scivoli, G.; Du, Y.; Wiemer, D. F. J. Chromatography A 2002, 966, 221–225.
Synthesis of a Carbon Analog of N-Acetyl Mannosamine via Acetolysis on a Relative Stable Ozonide. Chen, L.; Wiemer, D. F. J. Org. Chem. 2002, 67, 7561–7564.
A Cascade Cyclization Approach to Schweinfurthin B. Treadwell, E. M.; Neighbors, J. D.; Wiemer, D. F. Org. Letters 2002, 4, 3639–3642.
A One-Flask Synthesis of a,a-Bisphosphonates via Enolate Chemistry. Du, Y.; Jung, K. Y.; Wiemer, D. F. Tetrahedron Lett. 2002, 43, 8665–8668.
Stereoselective Synthesis of 5’-Hydroxy 5’-Phosphonate Derivatives of Cytidine and Cytosine Arabinoside. Chen, X.; Wiemer, A. J.; Hohl, R. J.; Wiemer, D. F. J. Org. Chem. 2002, 67, 9331–9339.

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